You have a lot of fires to put out. Werner, Chilwell, Mahrez probably have to go this week. Then there's the fact you have Bissouma and Brewster. Should only have one of them.
For Werner, probably Bamford is a good replacement. Seems to have the easiest fixtures of mid priced attackers.
I'd get Bruno in for Mahrez.
Maybe you can hold onto Chilwell another week to see if he recovers, but you're struggling to get 3 DEF out. You can either downgrade him to maybe Dias, Cancelo or Stones (but they're all at risk of being rotated), or you can change Masuaku to Coufal.
Next week you can think about what to do with Chilwell, Kilman and Bissouma.